The phrase "a major alteration of" is correct and usable in written English.
It can be used when discussing significant changes or modifications to something, such as a plan, document, or system.
Example: "The committee proposed a major alteration of the existing policy to better address the needs of the community."
Alternatives: "a significant change to" or "a substantial modification of".
He said the decision of the Court of Appeals "works a major alteration of the balance of power between the federal and state governments" that "deprives states of the power to enforce against national banks antidiscrimination laws and other laws".
None of them constituted a major alteration of the Lautner design, which includes a boulder jutting into the living room; she simply made interior modifications to make it "more livable," according to Linda Hope.
The calculated changes remain below 10% for most of the area, which does not indicate a major alteration of the hazard.
Taking together the ability of orexin in activating lfSCTR, we postulate a major alteration of ligand-receptor interaction of secretin and orexin by the advent of mammals.
The transcription factor, CEBPα is implicated in the regulation of numerous liver-specific genes and it is a critical regulator of hepatic metabolism [42] [46] and our results are in agreement with earlier reports [47], [48] that show a significant inhibition of CEBPα by TNFα thereby implying a major alteration of cellular metabolism.
Because of this, a major alteration of the extracellular milieu could also cause a collapse of the feedback loop.
Instead, the team found a major alteration in the brightness of the equatorial haze, which lies in a 16,000-kilometer wide belt over Jupiter's equator.
The inability of circulating ANG II to reduce PRA in PIH may constitute a major alteration underlying the pathophysiology of PIH.
A major alteration was the placement of the signature song "I Dreamed a Dream".
This effect was further supported by metabolic studies, which showed a major alteration in the synthesis of PC from choline and ethanolamine by the compound.
Rivera wrecks bats all the time, but what was unusual this time is that the bats belonged to right-handed hitters -- irrefutable evidence of a major alteration Rivera made in spring training, the introduction of a sinking fastball.
