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The phrase "a major advantage over" is correct and usable in written English.
It can be used when comparing two entities, highlighting the superiority of one over the other in a specific aspect.
Example: "The new software offers a major advantage over its competitors in terms of user-friendliness."
Alternatives: "a significant edge over" or "a key benefit compared to".
Exact(57)
This is a major advantage over data from ground-based instruments.
This kind of adaptability is a major advantage over traditional robots.
But, he added, "it's a major advantage over what we have now, which is nothing".
However, he has a major advantage over the other wide receivers.
"I've got a major advantage over Matt and that's being steeped in Scottish rugby.
That said, Gordon Brown has a major advantage over David Cameron.
Texas, however, has a major advantage over most other states: it can put the carbon dioxide to use.
CHDEP permits deuterium labeling of polyolefins prepared by any synthetic route, a major advantage over the traditional method of polymerizing deuterated monomers.
Valve has the largest PC gaming distribution platform and that is a major advantage over all other players in the PC VR space.
For Britain this represents a major advantage over Ireland and Spain, for instance, where house-building booms generated huge over-supply.
United and American would compete with each other for lucrative corporate contracts but would have a major advantage over the three other major airlines.
More suggestions(15)
a serious advantage over
a notable advantage over
a professional advantage over
a main advantage over
a valuable advantage over
a decisive advantage over
a tremendous advantage over
a large advantage over
a noteworthy advantage over
a fundamental advantage over
a distinguished advantage over
a great advantage over
a huge advantage over
a major task over
a major battle over
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com