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The phrase "a major actor in" is correct and usable in written English.
It can be used to describe someone or something that plays a significant role in a particular context or situation.
Example: "The company has become a major actor in the renewable energy sector, influencing policies and practices."
Alternatives: "a key player in" or "a significant contributor to".
Exact(26)
BlueOrchard Finance has been a major actor in this arena through the management of the Dexia Microcredit Fund (DMCF).
At the time of the leak, HSBC Switzerland was a major actor in the offshore wealth management industry.
With its numerous assets, EFS can be ambitious and assert itself as a major actor in cell and tissue engineering in Europe.
The public understands the difference between the state being forced to intervene to stabilise the market and government back in fashion as a major actor in the economy".
While being a major actor in the nuclear reactor business with proven light water technology, AREVA wishes to be ready to meet the new challenges calling for small grid requirements, high temperature process heat and cogeneration.
The effect of different functionalization strategies on MSC migratory behavior from the μCs is studied in vitro in relation to SDF-1α/CXCR4 axis, – a major actor in MSC recruitment, chemotaxis and homing.
Similar(34)
He's now a major actor, but in a specialized way: he doesn't extend himself much, and it's initially hard to imagine him as what he's supposed to be in "Broken Flowers," an indomitable Don Juan who leaves dozens of disappointed girls in his wake.
Thus, TRAIL likely represents a major actor involved in the immune surveillance against ocular tumours as well as modulator of the inflammatory and angiogenic response in the eye.
UNICEF is now recognized by Governments and development partners as a major actor of change in the sanitation sector.
Inflammation is an important trigger of neurodegeneration during aging ("Inflammaging") (Franceschi et al., 2000) and considered as a major actor of neurodegeneration in AD.
David Edelstein of New York Magazine stated: "Gosling looked like a major actor as a skinhead in The Believer and a star in Half Nelson.
More suggestions(16)
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a major representative in
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a major lapse in
a nō actor in
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com