The phrase "a main substrate of" is correct and usable in written English.
It can be used in scientific or technical contexts to describe a primary material or substance that serves as a foundation for a process or reaction.
Example: "Glucose is a main substrate of cellular respiration, providing the necessary energy for metabolic processes."
Alternatives: "a primary substrate of" or "a key substrate of".
Since ornithine is a main substrate of bacterial OCD [ 8, 17], we determined the effect of Orn on AtOCD expression by treating Arabidopsis seedlings with 10 mM Orn.
Thus, H4K20me1 is a main substrate of SUV4-20H to promote H4K20me3, which explains the accumulation of H4K20me1 in the SUV4-20H dn MEFs (Fig 4C; supplementary Fig 3 online).
Knock down of APP also significantly reduced the phosphorylation of FOXO, a main substrate of AKT and a transcription factor that regulates cell cycle progression through induction of cell cycle inhibitors including p21cip1 and p27kip1.
Several lines of evidence have implicated the dorsal raphe nucleus as a main substrate for modulation of nocuous stress.
Livestock dung has been used as a main substrate for growth and development of E. fetida; some agricultural wastes with it are also used for the improvement of the growth and reproduction of the earthworm.
In sepsis, inhibition of pyruvate dehydrogenase limits pyruvate conversion to acetyl-coenzyme A, the main substrate of the cycle [ 58].
As indicated by its name, cellobiose is the main substrate of the enzyme [ 5– 9] indicated by a low Michaelis Menten constant.
Experiments were conducted for one year in eight VFPCWs, the main substrate of which consisted of river sand at four of the wetlands, or a mixture of sand and dolomite (10 1 weight ratio) at the other four wetlands.
Because oxygen is the main substrate of the ETC, hypoxic conditions consequently decreases mitochondrial function and initiates expression of a host of genes that are needed for compensatory ATP production by glycolysis.
Since pyruvate is the main substrate of brain mitochondria [31], extramitochondrial Ca2+ is able to adjust the supply of OXPHOS with its main substrates precisely and reversibly, like a physiological "gas pedal", acting in response to distinct, Ca2+-mediated cellular demands.
Most importantly, these treatments were not effective for eliminating very low-molecular-mass DNA fragments (shorter than 200 bp), the main substrate of ancient and often forensic DNA analyses (e.g., [44], [45]).
