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Some Democratic advocacy groups, including the Progressive Change Campaign Committee and Democracy for America, insist that a main problem with the legislation is that it is not progressive enough.
However, there is a main problem with them that not consider proportional variability and focus on the absolute magnitude of changes.
A main problem with studies in vivo is the accessibility of the affected organ to the drug.
A main problem with heterologous expression of xylose transporters is inefficient targeting to the plasma membrane.
The high false positive rate of CEA testing in CRC, which often results from incidental rises in CEA caused by benign gastrointestinal disorders, has been a main problem with its use.
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Most worksheets involve a main problem that includes a problem statement with relevant information students need to use to solve the worksheet.
Solentview wrote: "Unfortunately, this site seems to have taken a bit of a hold on me and I can't seem to stay away from it, I think I may be addicted … Nurse!!!!" and kizbot shared a similar dilemma: "The main problem with Cif is that once you start, it's nigh on impossible to stop".
Huge trade surpluses helped to drive incomes upwards, and egalitarian business practices allowed domestic companies to siphon off much of the wealth.After more than a decade of stagnation, the main problem with these sectors now is a socialised financial system that does not encourage weak firms to go out of business.
The main problem with a Si slab IIR resonator as a filter is that its finesse is low.
Mallory Duncan, senior vice president and general counsel for the National Retail Federation, said in an interview that the main problem with the Fed's new fee structure was that it allowed banks and card companies to add up to 5 basis points — or five one-hundredths of a percentage point — to each transaction to recover a portion of fraud losses.
In more innocent times, I would assume this was a coordinated move by Wilshaw and Gove to construct a picture in which the main problem with education was feckless parenting, so the main policy levers should be the punishment of fecklessness.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com