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The phrase "a main problem is" is correct and usable in written English.
It can be used when introducing a significant issue or challenge in a discussion or analysis.
Example: "In our research, we found that a main problem is the lack of funding for essential programs."
Alternatives: "a key issue is" or "a primary concern is".
Exact(7)
A main problem is the lack of a discernible end to the spreading protests.
A main problem is, however, the lack of experimental data in the literature.
It is iterative and a main problem is solved each iteration.
A main problem is bubble formation in microelectrodes which has an impact on the electrical properties of the electrode and thus it influences the quality of the recording.
In science education, a main problem is overcoming false preconceptions and naive beliefs.
A main problem is the absence of a 'gold standard' against which to compare indicators.
Similar(53)
"Everybody Hates Chris" is the first show in a long time centered on a teenager whose main problem is not adolescent angst, but real life.
Second, it adds a new source of financing to a system whose main problem is unsustainability due to cost.
If a drug's main problem is that it's toxic to off-target organs, then nanotechnology can ensure that it's delivered to diseased cells instead of healthy cells.
Other economists said Mr. Feldstein's concern about an asset-price bubble seemed out of place when discussing an economy whose main problem is declining prices and demand.
(IDI with a community representative) The main problem is that the current system used by the district is not good.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com