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The phrase "a main problem for" is correct and usable in written English.
It can be used when discussing a significant issue or challenge that affects a particular person, group, or situation.
Example: "The lack of funding is a main problem for the development of new technologies in the region."
Alternatives: "a major issue for" or "a significant challenge for".
Exact(7)
"He's sitting on an energy source that's critical to us". A main problem for the United States is that Washington has little, if any, influence over Caracas.
Political analysts say a main problem for Democrats is that Mr. Graham is already off and running hard and fast, supported by a unified party and well positioned to raise the $8 million or so needed for a credible campaign.
Introduction Nosocomial infections are a main problem for public health for their cost as well as for the morbidity and mortality they generate.
It should be noted that the above studies [5 17] are based on line-of-sight (LOS) assumption which may lead to severe degradations since non-line-of-sight (NLOS) propagation is a main problem for accurate localization in actual WSNs system.
However, the determination of the right amount of penalization for these methods has remained a main problem for which no satisfactory solution exists [ 20].
A main problem for scientific research has been the lack of validity of currently used DSM/ICD-10 depression diagnoses [ 2, 3], which are not based on empirical evidence but on clinical consensus, leading to diagnoses with arbitrary boundaries and much overlap [ 4].
Similar(53)
"If it's true, it's a huge breakthrough, because the main problem for battery cars has been cost," David Cole, chairman emeritus of the Center for Automotive Research, a nonprofit research group based in Michigan, said in a telephone interview.
But in the situation when CF is not the main problem for a system, the MFS signal like f 9, t) could still be an attractive excitation signal because it covers a large frequency range.
The main problem for Sock was a lack of a clear game plan.
Also, I have an older iPhone, so the main problem for me is how slow the camera is.
It was described earlier and requires the daily exchange of network blacklists on an international basis, and its main problem for two decades has been lack of coverage.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com