The phrase "a main mediator of" is correct and usable in written English.
It can be used when discussing the role of a person, organization, or factor that facilitates or influences a process or relationship.
Example: "In the negotiation process, she served as a main mediator of communication between the two parties."
Alternatives: "a primary facilitator of" or "a key intermediary of".
Consequently, LRP-1 appears as a main mediator of adhesion disruption through regulation of the ERK and JNK signaling pathways.
If FASN were a main mediator of p63 function also in human tumors, the levels of the two proteins would be positively associated in SCC tissues.
PI3Kγ is expressed in hematopoietic cells acting as a main mediator of proliferation, differentiation, migration and survival of leukocytes.
NO is released from endothelial cells mainly by eNOS and is a main mediator of endothelium-dependent vasodilatation.
This cytokine is a main mediator of the inflammatory process, which is immediately released upon exposure to minimal pyrogenic stimulation and can be readily measured by ELISA.
Although we identified AMPK as a main mediator of autophagy that is controlled by calcineurin, we did not exclude other mechanisms.
Indeed, although caspase-1 is the main mediator of a proinflammatory response and chronic inflammation, it is also associated with tumor development.
Once a tumour has outgrown the tissue blood supply, the reduced concentration of oxygen stimulates the stabilisation and activation of the hypoxia-inducible factor (HIF), a transcription factor that is the main mediator of the cellular response to hypoxia (Kaelin and Ratcliffe, 2008).
Previously, the effect of ozonated serum on HUVEC has been investigated and a dose-dependent increase of hydrogen peroxide as the main mediator of ozone action (possibly through an increase of NO production) was shown [ 28].
A recent report identifies CAMKKβ as the main mediator of the E2-dependent activation of AMPK in human endothelial cells [ 43].
We used the change in HbA1c during the study period as the main mediator of interest in our causal mediation analysis.
