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A main issue that arises when applying kernel graph methods to genomewide networks is the computing time.
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Mr Phosa pointed to a crisis of legitimacy in South Africa's institutions as the main issue that needed to be discussed.
Today, the main issue that remains is care coordination, which is an integral part of reducing fragmented and duplicitous care, and which is a significant cost driver.
That's the main issue that drove us," he says.
The main issue that needs to be addressed for DRM is the deactivation of catalysts by sintering and carbon formation.
This is the main issue that needs to change, urgently".
The main issue that seems to be the matter of concern is Iran's nuclear program.
"There is one main issue that is central to the rest, and that is the issue of war and peace," Gabbard told Jones.
When driving, the main issue that comes across smaller people driving trucks is seeing while making turns.
Indeed, the main issue that an engineer or an architect must face when he/she decides to build a straw bale house is the absence of certain data about technical performance.
But, one might ask, isn't the main issue that Assad is a killer, and that children are dying in Douma?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com