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DDD is given to each ATC code and is the assumed daily average maintenance dose when used for a main indication.
Motor impairment is, however, difficult to use in the selection of patients for "no surgery", as this parameter is a main indication for surgical treatment.
As a main indication the disease comprises chronic inflammation of pheripheral joints, resulting in progressive destruction of articular cartilage and bone [ 2].
The increase in the abundance of sialic acid on sperm surface is a main indication of sperm maturation, which is also the major contributor of the negative charge of sperm [ 4].
Since CHD is a main indication for lipid-lowering medication use, we expect that the medication use is more common among persons with a history of CHD already before the diabetes diagnosis.
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ADD is an assumed average daily dose per animal, defined as the daily maintenance dose for a drug used for its main indication in a specified species.
Data on the different POA types dispensed in Canada during the study period were converted to DDD values – the assumed average maintenance dose per day for a drug used for its main indication for an average adult – according to the World Health Organization's (WHO) Anatomical Therapeutic Chemical (ATC) classification and DDD measurement methodology [ 33, 34].
The DDD is the assumed average maintenance dose per day for a drug in its main indication for adults and is commonly expressed with a certain population size denominator such as patient days, bed days, admission days, inhabitant days.
The DADDDK is specified per animal species and is a standardized dose in mg/kg per day for the main indication of a given active ingredient and a specified route of administration and pharmaceutical form.
The main indication that an egg is a quitter is the development of a blood ring.
For example the main indication of a valnemulin containing product has a dosage of 3 4 mg/kg per day, so the ADDDK is defined at 3.5 mg/kg.
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