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A main handicap of these devices is magnet field inhomogeneity, which significantly compromises sensitivity and robustness under practical circumstances.
Today, a main handicap with high throughput methods is the capacity for each individual research group to handle samples and data.
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A month ago, on the eve of the Republican convention, I wrote a post saying that Romney's main handicap wasn't his campaign manager or his tendency to trip himself up but the fact that he was running as the representative of such an extremist and unpopular party.
In fact, traditional radio's only advantage may lie in its main handicap: its ties to a specific region or city.
Although "La Gioconda" may be opera's answer to ballet's "Corsaire" (head-spinning plot, large ship onstage, hissable villain), Mr. Wheeldon's main handicap was not plot but an overly familiar score: "Dance of the Hours," branded into cultural consciousness by Disney's "Fantasia" (and Allan Sherman's "Hello Muddah, Hello Faddah").
However, its advantage is also its main handicap: high resolution allows the detection of a higher percentage of abnormalities than in a conventional karyotype but may also pick up unexpected findings and/or variants that are of unknown clinical significance [ 18].
So, Cassidy says, "I think the main handicap [Romney] faced wasn't that he was a weak candidate — although he wasn't a great one — it was that he was representing the Republican Party, which is out of step with large portions of the country on a lot of issues".
Her main handicap, Italian roots, is rarely mentioned.
Mr Netanyahu's main handicap is that as finance minister in 2003 he designed the reforms that impoverished so many of them.
The main handicap of the concentrating solar power technology is still the higher cost compared with the conventional coal power plant.
The main handicap of the busulfan treatment in rat models was the possibility of severe destruction of niche, especially Sertoli cells in testes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com