The phrase "a main drawback in" is correct and usable in written English.
It can be used when discussing a significant disadvantage or limitation associated with a particular subject or situation.
Example: "One main drawback in using this software is its high cost, which may not be feasible for small businesses."
Alternatives: "a major disadvantage in" or "a significant limitation in".
Hydrophobicity of poly l-lactide) scaffolds is a main drawback in obtaining a sufficient mass of seeded cells for satisfying the requirements of tissue engineering.
A main drawback in the development of new compounds is the lack of technologies to assess antagonist action in an in vitro situation as well as in living cells.
A main drawback in both mentioned studies was that all parameters were considered deterministic despite the fact some of them should be predicted for the future periods in a dynamic environment with high level of uncertainty.
This is a main drawback in connection with high speed OCT, since maximum permissible exposure needs to be divided between all active channels, which may lead to lower than acceptable sensitivities on each of these channels.
We are convinced, that a main drawback in current clinical practice and research is that the precise content of interventions is often poorly documented (what were therapist and patient really doing during intervention?) while, on the other hand, different terminology may be used to address similar approaches.
As a main drawback, highlights the need for change in posture of the patient during surgery, which stretches, although not overly, the operative time.
The main drawback in using an individual phylogeny as a starting point for the algorithm is the potential of wrongly inferring reassortment events if the start topology is incorrect.
The K. varians identification was based on Vitek-2, which showed a relatively reduced probability level (93%); however, the main drawback in this case was the lack of a 16S rRNA gene sequence analysis for species confirmation.
The main drawback in changing to a new response format is that it precludes direct comparisons between previous and new research.
"But the main drawback in tracking stocks is that they create significant potential conflicts of interest among stockholders, the board of directors and management".
It actually becomes the main drawback in applications of complementary sequences to multicarrier systems.
