The phrase "a main difference between" is correct and usable in written English.
It can be used when comparing two or more items, concepts, or ideas to highlight a significant distinction among them.
Example: "A main difference between cats and dogs is their social behavior; cats tend to be more independent, while dogs are often more social and loyal."
Alternatives: "a key difference between" or "a significant difference between".
If there is a main difference between his prime-time show and his current incarnation, Mr. Scarborough said, it is that he feels liberated.
A main difference between swine flu and seasonal flu is that people over 60 appear to have some immunity to swine flu, while younger people seem not to.
But even if the science cannot prove it, you should accept that there is a main difference between righ-handed and left-handed people.
The wrinkles stem, in part, from a main difference between the new federal insurance marketplace and routines elsewhere in the health-insurance industry.
WASHINGTON — House and Senate Democrats announced a tentative agreement Monday to impose new limits on debit card fees, which would resolve a main difference between the two chambers as they race to complete financial legislation before the Fourth of July.
There is, however, a main difference between the sense of ownership and the feeling of familiarity.
While you watch the video, note down what Olivier says about a) the main difference between distance learning and face-to-face learning and b) the three advantages of distance learning.
Let's begin with a generalization: the main difference between going to a concert in Manhattan or in Hollywood is the intent.
Although the terms incubator and accelerator get thrown around a lot, the main difference between these two entities has historically been that incubators are a shared work space with many other startups and no particular ending date to their stay.
BOTH kinds of shopping areas generally serve people within a radius of a mile and a half, but the main difference between the two is the size of the stores included on the properties, Mr. Fedelem said.
But Mr. Leno said in an interview: "The main difference between this and the other time is I'm part of the process.
