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The phrase "a main change in" is correct and usable in written English.
It can be used when discussing significant alterations or modifications in a particular context, such as a project, policy, or system.
Example: "The report outlines a main change in the company's strategy that aims to improve efficiency."
Alternatives: "a significant change in" or "a major shift in".
Exact(1)
That triggered what became a key issue in the FTC investigation and, eventually, a main change in the settlement this week.
Similar(59)
The main change in the measure involved a single verb, so that what had been parallel condemnations of suicide bombings by Palestinians and extrajudicial killings by Israelis were weighted differently.
The main change in timing appears to be a reduction in repairs performed after the age of 2 years.
The main change in attitude lies in the grammatical perspective, a shift in tense from future perfect to present continuous.
The main change in the surgical procedure was to remove a 5 mm diameter area of dura mater.
The main change in depocentre location occurred at ca. 28,000 cal a. BP, with the northward avulsion leading to the formation of the Middle Channel.
Dale: The main change in cooking is just really concentrating on the flavour.
"The main change in the company has been their renewed emphasis on profitability versus blindly going after market share".
"The main change in 20 years on the delta is that people are more conscious of the environmental horror they are forced to live in.
"But the main change in him over the years is that he has got softer and more open to his emotions.
Meanwhile, the links between prevention, al-Qaeda and host countries lead on to the other main change in the war against terror.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com