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The phrase "a main cause of" is correct and usable in written English.
It can be used to identify a significant factor contributing to a particular outcome or situation.
Example: "The researchers concluded that pollution is a main cause of the decline in local wildlife populations."
Alternatives: "a primary factor in" or "a significant contributor to".
Exact(60)
A main cause of the police walkout is unpaid back wages.
They note successive military coups in Pakistan are a main cause of the country's current malaise.
The Buenos Aires government coaxed most provincial governors to pledge to reduce local spending -- a main cause of runaway debt.
Those now go without saying, but violating the last one is still a main cause of breakups.
Problems with this system, known as full authority digital engine control, were a main cause of the delays.
This perceptual conflict is a main cause of visual discomfort.
Reinforcement corrosion is a main cause of durability deterioration of reinforced concrete structures.
Tidal recruitment of nonaerated lung is a main cause of ventilator associated lung injury.
Bleeding complications remains a main cause of increasing morbidity and mortality in patients under VV-ECMO.
Collision is a main cause of the failure of in-vivo particle transportation.
Mutations in the nebulin gene (NEB) are a main cause of recessively inherited NM.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com