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Studies on the relationship between total alcohol intake and circulating homocysteine levels have been inconsistent, but several studies have shown a lowering effect of beer drinking on plasma homocysteine concentrations, which has also been reported previously for this cohort [38].
In clinical practice, some studies have reported a lowering effect of losartan on SUA level.
To our knowledge, however, there is no clinical report that telmisartan may decrease SUA level, whereas some clinical studies have shown a lowering effect of losartan on SUA level.
Ye et al. have reported higher vaspin levels in subjects with T2DM and a positive correlation between vaspin and postprandial blood glucose levels [ 57, 58], as Li et al. described a lowering effect of continuous subcutaneous insulin infusion on serum vaspin concentrations concomitantly with the beta-cell function amelioration in T2DM [ 58].
It has been observed that some anti-inflammatory signals are induced during cold acclimation such as adiponectin [ 35] which in turn may compensate through the upregulation of BAMBI [ 36], thus counteracting a lowering effect of ascites on BAMBI expression from chicken in the cold group.
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The effect of climate was not very pronounced but a slightly lowering effect of annual precipitation on structure was found (Fig. 7c).
Animal study clearly suggested a cholesterol lowering effect of R-bambuterol in the treatment of tyloxapol-induced hyperlipidemia in mice (Cheng and Tan, 2009).
The number of patients required to establish a glucose lowering effect of GLP-1 was based on power calculations derived from our previous work [ 8].
In the QUARTET studies, a consistent lowering effect of pioglitazone on microalbuminuria (estimated as albumin-to-creatinine ratio) was evident, which was not seen with metformin or sulfonylureas (2, 3).
This could have introduced a confounding factor, as the absence of a blood pressure lowering effect of pravastatin in patients on placebo might have been compensated by more common addition of a second antihypertensive drug.
Our study did not find a blood pressure lowering effect of dark chocolate or tomato extract in a prehypertensive population.
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