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This tissue specific expression of the isoform is often accompanied by a lowered expression of the other isoform(s).
A lowered expression of CYCS, however, would conceivably decrease the sensitivity to stress-induced apoptosis [ 21].
Impaired glucokinase activity and a lowered expression of GLUT2 have been connected with impaired insulin secretion [ 23, 24].
One could speculate that, all other factors being equal, susceptibility to BSE might be reduced with a lowered expression of endogenous prion protein.
In patients with heart disease, PRMT1 is observed at elevated levels, as well as a lowered expression of DDAH, which metabolizes ADMA.
These results suggest that GFW alleviates colonic inflammation by suppressing production of TNF-α and its signaling through NF-κB, which results in a lowered expression of pro-inflammatory chemokines [ 21 ].
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In addition, mice treated with IFNβ had a 50% lowered expression of TNFα in the synovial tissue [ 28].
DNA microarray profiling revealed a lower expression of neuron-derived orphan receptor-1 (NOR-1) in elongated SMCs.
A lower expression of receptors means fewer targets on the cell surface for the medicines, he says.
As compared to F4/80Low cells, F4/80High cells displayed a more immature status with a lower expression of CD40, MHCII and PDL1, and a higher phagocytic activity.
Thus, these findings suggest a lower expression of OCT2 in Tg mice to be responsible for the reduced TBC of 11C-metformin.
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