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Human dermal cells isolated by plastic adherence had a lower differentiation capacity as compared with bone marrow derived MSCs.
We have consistently observed a lower differentiation capacity of stable cell lines compared to cells that are only transiently transduced.
As a consequence, the suprabasal layer of JE has a lower differentiation but higher regeneration ability than the basal layer.
A lower differentiation grade of donor material correlated with a higher CDCP1 mRNA expression level in the respective tumour model.
This pre-existing DNA damage was increased upon etoposide treatment in a similar way as in control cells of a lower differentiation stage.
Further population genetic analyses based on 1244 polymorphic AFLP loci demonstrated a lower differentiation between allopatric than sympatric populations of the C. albula complex and suggested a rather complex colonization history than simple sympatric speciation [ 6].
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The disease resistance genes as a group have significantly lower differentiation than the genome average by an even greater extent (p < 0.001), according to the permutation tests (Table 2).
In contrast to other tumour parameters and treatment arm, a significant association of G category and BSI was detected with tumours of lower differentiation showing a decreased level of BAX protein expression (P=0.01).
AFLP loci potentially under selection (outlier loci) were identified using the BAYESCAN software [ 71] by assuming that loci influenced by directional selection show larger genetic differentiation than neutral loci, and loci that have been subjected to balancing selection show a lower genetic differentiation.
However, there was a trend (p = 0.12) towards a higher frequency of N0 patients with lower differentiation grade in the BM2 sampling group.
Loci under balancing selection are predicted to own a higher variation within population, but lower differentiation between populations when compared with neutral or nearly neutral markers, assuming that the selective pressures in the two populations are similar [ 62].
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