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Genetically, a lower constraint associated with these characteristics could allow nGPCR genes to better tolerate deleterious random mutations and accumulate beneficial mutations, thus allowing nGPCR duplicates to be fixed with a higher probability as compared to genes with average constraint (Fig. 6B).
Application of our modeled relationship provides a lower constraint of the timescale of the sintering interval over which porosity can be reduced to the values observed in the deposits under ambient pressure conditions, that is, neglecting the load of the overlying flowing mass.
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Higher dN/dS in conifers could be due to a general low mutation rate and a high selective constraint on synonymous mutations, which seems at odds with the neutral expectancy but cannot be completely ruled out, or a general very low mutation rate but a proportionally lower constraint (relative to angiosperm genes) at non-synonymous sites.
However, an Upper Triassic age cannot be completely ruled out at the moment, as there is not a well-defined lower constraint for the age of this unit.
Lin et al. [5] proved the existence of equilibria for generalized abstract economy with a lower semicontinuous constraint correspondence and a fuzzy constraint correspondence defined on a noncompact/nonparacompact strategy set.
The genetic programming-based methods we discussed discover motifs as a sequence of segments which are either single stranded or complementary, with a bound (upper and lower) constraint on their lengths.
For instance, the loads and partitions that correspond to a "fair" rate tuple can be obtained by maximizing for an appropriately chosen set of weights, subject to the constraints in (10a)–(10f) and, possibly, a lower bound constraint on.
If a distance exceeds the upper or lower constraint limit by d Angstrom, then the penalty score Ec is d*d when d<0.5 and d−0.25 when d≥0.5.
miR and miR* regions typically show the greatest constraint and hence the lowest rate of substitution, while the loop and stem regions, although important for processing, show lower constraint and hence a higher rate of substitution (Fahlgren et al. 2010).
Open image in new window Fig. 1 Stiffness pattern diagram, without a lower bound constraint.
Due to some near-zero values for stiffness, the obtained formulation will be modified by adding a lower bound constraint.
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