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However, the findings of this study support a US study of long-term care facilities, in which residents with dementia were found to have a low sedative load [ 26].
Approximately one-third of residents were not taking any medications with sedative properties at each time-point, while a significant proportion of residents had a low sedative load score of 1 or 2 (54.8%, 59.0% and 57.1% at baseline and time-points 2 and 3 respectively).
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Formal trials of psychotropic drugs with low sedative loading in care home residents with dementia should also be undertaken.
In our study, the two mouse strains responded identically to low, sedative concentrations of dexmedetomidine; higher doses produced non-stimulus challenged LORR in both strains.
Together, the persistent loss of ability to adapt to changes, low sedative response to alcohol, and increased sensitivity to cognitive disruption associated with adolescent alcohol exposure all are likely to promote and sustain high alcohol-drinking levels.
Second-generation antihistamines are differentiated from the first-generation antihistamines by their increased specificity and efficacy toward histamine H1 receptors, and the low sedative effects due to their much lower penetration into the CNS.
This could result in a low requirement for sedatives [12].
Although trazodone is often used at a low dose as a sedative-hypnotic in depressed patients (as monotherapy or in combination with other antidepressants), as well as in conditions other than depression (i.e. primary insomnia), clinical evidence supporting its use in these settings is limited and further studies should be implemented.
If it is necessary to administer sedatives, the patient should be carefully monitored; if there is confusional symptomatology, then a combined regimen of a sedative at a low dose and a neuroleptic should be administered.
Except for one patient, who received DEX as a single drug after suspension of other sedatives, a low-dose infusion of another sedative (<50% compared with initial dose) was maintained.
"It has a low margin of safety and can cause toxicity at doses that are not much higher than those used to produce a sedative effect," said Dr. Rick Sams, who runs the drug testing lab for the Kentucky Horse Racing Commission.
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