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We know that the PAML search algorithm did occasionally stall at suboptimal local optima in the analyses of our simulated data, since in around 1 2% of cases we obtained a higher likelihood with the simpler model, but such a low proportion is only expected to cause a slight downward bias to our simulation p values.
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With the current poor survival, low therapeutic responsiveness, and vast molecular heterogeneity of PDAC, even if a relatively low proportion were found to be HER2-amplified, targeting by HER2 amplification represents an attractive potential therapy.
Heterogeneity and redundancy are two significant characteristics of mRNA expression, and while the majority of mRNAs are expressed at low levels, a small proportion is highly expressed.
In the following year, low proportions were observed in spring 20111).
Since such a low proportion may be attributable to polymorphism at the probe CpG sites, these 60 probes were excluded from this assay, leaving a final total of 26426 autosomal CpG sites.
The lowest proportion was in London.
The areas with the lowest proportion are the north-east (10.8%), followed by Scotland at 11.5%.
This is the first report on the existence of dogs having the positive level of antibodies against Erysipelothrix with 5% prevalence, even if it is a low proportion, indicating there was a certain risk of Erysipelothrix infection among dogs in the field.
The majority of patients with RA are women, a low proportion of whom are employed in certain countries at disease onset.
It is not surprising that a low proportion of oligonucleotides were unable to hybridize with their intended targets especially if they were designed in regions with low confidence in sequence quality.
Discussions in which a high proportion of the discussion was spent exchanging reasoning or a high proportion was spent exchanging claims were no more likely to produce a high correct revote than were discussions in which a low proportion of time was spent on reasoning or claims.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com