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In GBM, although additional prognostic factors would certainly had provided stronger validation, the low number of tumors with 1p centromeric loss detected (n = 9) resulting from a low frequency event (8%), was sufficient to reach high statistical significance (P = 0.0175).
The common metric for predicting the onset of coral bleaching – one month with SSTs that are 1°C greater than the maximum monthly mean (MMM) – is a description of a low frequency event in the majority of the tropical ocean.
We interpret our results to indicate that aberrant pre-mRNA splicing in GBM is a low frequency event.
Because oral disease is a low frequency event at the population level, we asked parents or caregivers to consider the child's entire lifetime's experience of dental disease and treatment when responding to the ECOHIS.
The evolutionary mechanism underlying the above distinction was investigated using gene conversion analysis, and it was apparent that non-reciprocal sequence exchange was a low frequency event between paralogs in the DM/RH/HB ortho-haplotype, a feature diagnostic of Type II R-genes.
P element swapping (Sepp and Auld, 1999) is a low frequency event, but the lines were constructed with UAS/GFP as a marker for Gal4 activity, and thousands of first instar larvae could be quickly screened for one with the expected segmentally-restricted GFP pattern.
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However, the appearance of these clones was a low-frequency event.
"It's a low-frequency event, but it's devastating," Dr. Mega said.
Chromosome 1p is particularly interesting, as the amplicon in this region has not been previously noted in ovarian cancer, most likely because it is a highly focal, low frequency event (3% at log2 >1, 23% at log2 >0.3) that would likely only be detected with a large dataset of high-resolution arrays.
We must avoid a further tragedy through the introduction of human factor-based risk such as fatigue, stress and other well-being concerns that increase the likelihood of a high consequence - low frequency event".
Severe accident analysis of such low frequency event provides insight into the accident progression and basis to develop the severe accident management guidelines (SAMG).
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