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Patients with MDC1A experience a longitudinal decline in FVCpp.
The strength of such a longitudinal decline is modified by the investigated EPHX1 polymorphism [ 70].
Evidence shows that students experience a longitudinal decline in behaviors and attitudes toward ethical and social issues in medicine as they go through medical school[ 23, 28].
The aim of the present study was to evaluate the association of plasma sRAGE levels with a longitudinal decline of lung function.
For smokers with COPD, a trend became evident between a decreased plasma sRAGE level and a longitudinal decline in FEV1 (Table 3, Additional file 1: Figure S1).
37– 39 Perry et al 40 also described that there is a longitudinal decline in 25(OH D levels with aging, even in those taking a vitamin D supplement.
Similar(54)
Ohkura et al. found that eNO was not a risk factor for longitudinal decline in forced expiratory volume in 1 second in asthma patients even if their asthma was stable and well controlled by ICSs.
However the primary MRI analyses of the trial showed that although people in a intensive glycemic treatment group had less longitudinal decline in total brain volume at 40 months compared with those receiving a standard treatment strategy (P = 0.0007), no significant differences were found in the cognitive outcomes between the two treatment groups (14).
In the present study, we evaluated plasma concentrations of sRAGE and HMGB1 in non-smokers, smokers without COPD, and smokers with COPD, and we subsequently examined the association between these two markers using baseline demographic data and the longitudinal decline of lung function during a 4-year follow-up period.
The cross sectional effect of age at baseline (dropping 0.24 units a year, P=0.001) did not significantly differ in magnitude from the longitudinal decline among controls over follow-up surveys, which is consistent with the longitudinal decline being a pure maturation effect (that is, the adolescents growing older) rather than a repeated survey effect.
A recent report from Fouladi et al. also showed no significant longitudinal decline of IQ measures of patients with infratentorial tumours who received local RT compared to CSI [ 26].
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