Sentence examples for a long-standing difficulty from inspiring English sources

As we noted at the beginning, the absence of any information about the reaction intermediates has been a long-standing difficulty that has hindered progress and the precise mechanism has yet to be established.

A long-standing difficulty in understanding the specificity of T cell recognition is to reconcile the hypothesis that T-cell activation is determined by the lifetime of TCR-pMHC bond and the finding that widely different responses are induced by pMHCs that are bound with dissociation rates differing by a factor lower than 10.

Just days before Mitt Romney formally assumes the leadership of his party, he and his Republican colleagues are once again confronting the party's long-standing difficulty attracting the support of women — a demographic reality that could cost Mr. Romney the White House.

One main reason for this situation has been the long-standing difficulty of demonstrating intercisternal continuities in thin sections for electron microscopy.

Mr Kershaw will examine the long-standing difficulties at the trust before publishing a draft report on 29 October.

In a Regulatory Notice, the HCA said there were "chronic and long-standing difficulties" in the delivery of the repairs service to 13,000 homes in the London area covered by Circle 33 and Old Ford Housing Association, which are part of CA. Over a period of three months in Circle 33's 8,000 homes, less than 20% of urgent and emergency repairs were completed on time, the HCA said.

In the meantime, the knowledge of the Soviet-bloc countries' long-standing difficulties had given rise in many developing countries to a repugnance to Soviet planning methods, while the methods used in the developed noncommunist countries were felt to be not directly applicable, either.

A briefing paper from NHS England describes the targeted localities as having deep-rooted and long-standing difficulties that are in need of transformation.

(U) Lastly, U/S Burns asked for the President's assistance in resolving the long-standing difficulties in finalizing the lease for the new Embassy compound.

Interviews revealed the long-standing difficulties of living with HIV, particularly in the domains of intimate relationships, perceived stigma, and chronic ill health.

In the field of mathematics, studying the limits of systems of particle systems in interaction has been a long-standing problem and presents many technical difficulties.