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Although it may have been frustrating for Hans Toni that for a long time effect models in environmental risk assessment were only reluctantly accepted, it certainly will enjoy him that now his students play an active role in the promoting and further development of effect models as tools for higher-tier risk assessment [16 18].
We found that METH binge, given at early life (week 6 8 in mice), potentiated the reduction of TH and DAT immunoreactivity in striatum and nigra after a second METH binge, given at 5 month later, a long time effect which has not been reported previously.
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Tracer tests, reported later in this paper, speak in favour of a combination of different time scales of the watering-dewatering effects: one between hours and days and a long-time effect over months.
At the same time, we can see vancomycin did not kill transplanted microbes in a short period of time, but long time effects still needs further study.
The first observations of this go all the way back to the 1850s, and for a long time the effect was studied with regard to small inorganic molecules and polymers, but in recent years scientists realized it could be a useful way to track the behavior of larger biomolecules, too.
But for a long time the effect of CR on longevity remained just a phenomenon, albeit an important one.
The oblique helicoidal (heliconical) state has been predicted by Meyer and de Gennes to occur in the applied electric field in a cholesteric in which the elastic constant of bend K3 is much smaller than the elastic constant of twist.[ 20, 21] For a long time, the effect could not be explored because of lack of materials with the needed elastic properties.
But just as nuclear waste remains radioactive for a long time, the effects of carbon dioxide persist.
For a long time, beneficial effects in stem cell therapy were contributed solely to cellular mediated mechanism.
When patients with osteoporosis are treated with exogenous oestrogen for a long time, side effects such as endometrial hyperplasia, uterus and breast tumour would occur [ 4].
Even a brief course of antibiotics can disrupt the balance for a long time; the effects on intestinal microbiota have been shown to persist even after 2 years [ 18].
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