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As we noted at the beginning, the absence of any information about the reaction intermediates has been a long-standing difficulty that has hindered progress and the precise mechanism has yet to be established.
A long-standing difficulty in understanding the specificity of T cell recognition is to reconcile the hypothesis that T-cell activation is determined by the lifetime of TCR-pMHC bond and the finding that widely different responses are induced by pMHCs that are bound with dissociation rates differing by a factor lower than 10.
Mr Brown promised £150m of rapidly delivered agricultural compensation for farming and industries which "today face long standing difficulties".
He received a long standing ovation.
The audience gave him a long, standing ovation.
This confirms a long standing expectation.
Martin received a long standing ovation from fans.
Unfortunately, this is a long standing systematic problem.
This science has a long standing history in developing countries.
Chronic illnesses require a long standing or lifelong adaptation.
Outline sketch the head with a long standing rectangle.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com