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Objective: To compare the pregnancy rates of frozen-thawed 2-pronucleate (2PN) oocytes obtained either in a long protocol or in an antagonist protocol and ovarian stimulation with either human menopausal gonadotropin (hMG) or recombinant follicular stimulating hormone (recFSH).
Ovarian stimulation was performed using a long protocol, with pituitary down-regulation with the gonodatrophin releasing hormone (GnRH) agonist Supercur (Aventis Pharma Ltd ,Kent, UK) commenced in the mid luteal phase of the previous cycle and continued until ovulatory human chorionic gonadotrophin (hCG) was given [24].
Patients underwent COS following down-regulation with a GnRH agonist in a long protocol.
Controlled ovarian stimulation is performed through a long protocol as previously described [ 14].
Our standard protocol was based on OC pretreatment from the 2nd to 4th day, which is considered a long protocol with mild pituitary suppression, using 0.1 mg triptorelin every 2 days.
In symptomatic subjects methacholine challenge was performed according to a long protocol of doubling the cumulative dose of methacholine after a starting dose of 7.8 μg up to a cumulative dose of 2 mg.
Similar(50)
Subgroup analyses done to include only women downregulated with a GnRH-agonist long protocol or whose embryos were fertilized using standard IVF have shown a higher probability of success with hMG and HP-hMG.
In both studies, the patients were treated with HP-hMG or rFSH in a GnRH agonist long protocol.
Having in mind that those patients had previously at least two IVF attempts with protocol including agonist downregulation, as well as the fact that for 81% of patients in group A (control group) long protocol was used, difference in oocyte quality and increased pregnancy rate should be addressed to LH priming.
group 19 patients underwent a long stimulation protocol and 17 a short protocol.
A higher percentage of Indian patients had the long protocol and a higher percentage of Caucasian patients had an antagonist protocol.
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