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As well, these results corroborate data obtained in cats, showing a long lasting response synchronization [8] or receptive field plasticity [10] of cortical visual cells after co-application of cholinergic agonists and light stimuli.
The median time to PSA progression was 126 days, indicating that multiple therapy cycles may be necessary to obtain a long lasting response.
In order to elucidate how Rage receptor signaling converts a transient stimulus into a long lasting response, global gene expression kinetics were recorded with skin samples of wt and Rage -/- mice upon TPA stimulation.
Three patients displaying a long lasting response to SM treatment (Table 1, Pts #6a,8a,10a; SD or PR according RECIST evaluation after ⩾10 months) consistently showed a low level of mMDSCs, with values comparable to HDs and no evidence of CD3+ T-cell dysfunction in the peripheral blood could be detected in these SM-responsive patients.
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Repetitive EA evokes a long-lasting response, suggesting that this therapy may be suitable for treating clinical hypertension.
A long-lasting response was defined as no cutaneous or in-transit relapse after a minimum of six months.
A long-lasting response was defined as no cutaneous or in-transit relapse after a minimum 6 months.
We found that approximately half of patients with a CR at 3 months (44.8%) maintained a long-lasting response (mean follow-up of over 2 years).
Although remarkable objective responses were observed, only a fraction of patients experienced a complete response and/or a long-lasting response with this mAb [ 8- 11].
We tested whether a single bout of IH could initiate a long-lasting response potentially leading to better adaptation to hypoxia.
This is in good accordance with other studies, where an EGFR mutation was associated with a long-lasting response [ 13] or high PFS in first-line therapy [ 14].
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