We propose that this coordinated approach to in vitro patient-derived iPSC study will enable a greater ability to characterize rare GRD at a cellular level and presents a logical pathway and opportunity for functional validation of genetic variants discovered.
In 2010, Rothem et al. [ 14] developed a logical pathway and benefit chain that identifies improved capacity, improved services and improved outcomes for clients.
The chapter emphasizes that the use of heterocyclic species, such as furan, pyrrole, thiophene, and pyridine, for the preparation of stable, hexameric (macro) molecular architectures has been demonstrated as a logical pathway to functional materials.
The 'inverted cone' approach to EQUIPT allows us to test the transferability of economic evidence in a logical pathway.
But I am excited about the finding because it provides a logical explanation for auditory pathway plasticity and it extends previous concepts that dealt with neuron survival in the auditory brain stem.
The latter effect was discovered within the context of the genotoxic stress pathway, and the fact that SIR2 is involved in the maintenance of genome integrity [ 56] would make it a logical target for that pathway.
Thus, the PD-1/PD-L1 pathway represents a logical target for cancer immunotherapy.
Because GIPC1 signal transduction is activated by a wide range of cell-surface receptors and because it is also known to be essential for branching morphogenesis of arterial blood vessels, targeting GIPC1 mediated pathways is a logical therapeutic strategy for the treatment of human cancers.
Crucially, the notation provides a logical context for interactions between components in the pathway, it can display the temporal order of reactions and can be mapped to the machine-readable SBML (systems biology markup language) [ 7].
The resulting hypergraph consists of 77 nodes (50 genes, 22 proteins, 3 extracellular metabolites and 2 intracellular metabolites) and 118 hyperedges, and represents a logical model for glucose repression signaling and regulatory pathways.
