Also, some biochemical functions necessary for fertility in vitamin A deficient male and female mammals originally appeared to require retinol for rescue, but this is due to a requirement for local conversion of retinol to RA, as administered RA does not reach some critical tissues unless given in high amounts.
These conditions might simulate a situation where there is both VEGF and VEGFf entering a cell environment due to local conversion of VEGF to VEGFf by NE rather than the case where excess VEGFf enters a cell environment.
However, it has never been determined whether neuronal contact triggers localization of receptor protein, or local conversion of non-functional receptors to functional receptors.
There is evidence that activated fibroblasts may arise from local conversion of dermal fibroblasts by soluble factors, a finding that is consistent with our CTGF staining data.
Estrogens can still be produced in postmenopausal women by tissue-specific local conversion of androstenedione to E1, and to a lesser extent T to E2, by aromatase (271).
Obesity, BMI over 30, is an imputed cause of EL [ 2- 4, 10, 12, 13] which provides a milieu for the enzyme, 11β-HSD-1 to convert corticosteroids to cortisol [ 14], Diet induced obesity leads to an increase in 11β-HSD-1 which increases cortisol by the local conversion of corticosteroids to the biologically active cortisol [ 14].
Indeed, only a small fraction of E2 would be released from the various tissues because of further local conversion of E2 into E1 and E1S, in addition to a series of polar metabolites (Fig. 1).
There is evidence that glucocorticoid receptor activation can be reduced selectively and safely within liver and adipose tissue by reducing local conversion of inactive cortisone to active cortisol by using an inhibitor of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) (12, 35).
The model provided the temperature at each point in the solid, the local conversion of solid, the time to smoldering, and the time to ignition of the material.
This GDEPT system aims to produce high level of CES at the tumor site, resulting in efficient local conversion of the TAX-2′-Et prodrug into the active drug TAX [A.
