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To accomplish this, we comprehensively searched for articles related to rice functional genomics and established a list of functionally characterized genes.
We examined published data and data available from The Saccharomyces Genome Database (http://www.yeastgenome.org/) concerning the functions of the genes showing SDI with actin and derived a list of functionally related genes we might expect to show SDIs with actin (the implicated genes).
As a result, for each drug and disease, we obtained a list of functionally interacting genes to represent drug or disease subnetworks.
It afterwards generates a list of functionally homologous sequences.
For the identification of candidate dioxygenase relevant to bioremediation, a list of functionally validated dioxygenases was used for the construction of BLAST database.
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For each "omic" database, a list of functionally-related "candidate" genes was retrieved and ranked on the basis of their corresponding similarity scores.
This algorithm compares genes that code for IDPs to a list of previously functionally annotated genes.
Table 2 shows a list of selected functionally related groups of genes that were differentially expressed (≥1.5-fold) in all treated spheroids.
This suggests that Spearman correlation is capable of capturing a larger list of functionally associated TFs, possibly because of its ability to capture those with a looser coordination in expression.
A core function "SearchGene" was developed to search functionally related genes for a gene, a group of GO terms, or even a list of biological functions.
Nevertheless, the differentially conserved residues and motifs identified here comprise a list of targets for functionally-directed mutational studies.
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