Pair (7, 9) is located in the loop connecting strand d from one repeat to strand a in the next repeat for and pair (25, 27) in a β-turn linking strand b and c within a repeat (fig. 4a).
Perhaps the fact that love is the primary linking strand between the stories in the new collection is an indication of this change, but Schlink says, "I had been thinking about these themes for a very long time, many years before I started on The Reader.
This specificity can be attributed to the presence of Gln66 in MgS at the loop linking strand β4 to helix α4b, replaced by Arg101 in GpgS (within the 310 helix α4a).
In this way, the linking strand DNA could hybridize to SS DNA.
This particular loop orientation is also seen in the six-bladed TolB β propeller, which has a similar consensus sequence (the AxSPD motif) linking strands A and B (Abergel et al., 1999; Chen et al., 2011).
The TRAF-C domain is known to form an eight-stranded antiparallel β-sandwich structure containing two twisted, four-stranded, antiparallel β-sheets and a long helical segment linking strands β1 and β2.
Two cysteines (Cys303 and Cys348 in DDR1) form an internal disulphide bridge linking strands β4 and β7; the unpaired cysteine (Cys287 in DDR1) is also buried and can be mutated without compromising DDR function [53].
These loops are exposed on the top face of the propeller blade as are the β-turns linking strands B and C in each blade.
In the native protein, disulfide bonds link strands G to H (Cys106 Cys119) and strand D to the C-terminal (Cys66 Cys160).
TIN2, through its interaction with TPP1 as well as both TRF1 and TRF2 provides a bridge, linking single-strand and double-strand binding proteins in the shelterin complex (reviewed in [ 3,26]).
