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A linkage, based on the NRN, between our cohort and the Swedish Cancer Registry as well as the Swedish Death Registry was performed to verify that controls were alive and without testicular cancer at the time of diagnosis of the corresponding case.
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First, we made 10.000 permutation tests to confirm the threshold of LOD score and chose strict statistical criteria for a significant linkage based on genome-wide data.
We agree with reviewers and would direct them to the co-submitted article by Campbell's laboratory that has the B4GAT1 deficient cells and determines the Xyl is terminal on alpha-dystroglycan in these cells and in a beta linkage based on glycosidase specificity.
This is a confidential probabilistic linkage based on the name, surname and date of birth of the deceased [ 17].
For each of these markers, a null model of random allele/chromatid segregation was generated using formulas for trivalent pairing with centromere linkage (Koller et al. 1996) with physical distance from the centromere used as a proxy for linkage based on 0.0038 crossovers per kilobase on chromosome XIII (Mancera et al. 2008).
This theory may be seen as a special case of a more general theory for linkage based on preservation of linkage disequilibrium under epistasis [ 27- 30].
For each phenotype, non-parametric linkage analysis was performed using MERLIN which constructs a likelihood ratio test for linkage based on inheritance vectors.
Developing a registry with administrative data linkage based on SIN may not be feasible in our region based on these results.
Third, there was correct linkage based on a combination of 'matching variables' (consisting of maternal and newborn characteristics) that were individually matched in a meticulous manner.
Fully automated record linkage based on a set of personal identifiers that are routinely collected at health facilities (S6 in Table 1) has a sensitivity of 75.28% and PPV of 90.89%.
When such a system is not available, probabilistic linkage based on several fields (including accounting for possible misspellings) provides a satisfactory substitute [ 22, 23].
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