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This approach is called a linkage analysis.
We started by performing a linkage analysis in a collection of 36 families with the aim to identify both general and family specific linked chromosomal regions.
We ran LOKI, a linkage analysis package for quantitative traits within large and complex pedigrees which uses Markov chain Monte Carlo techniques to calculate kinship coefficients between any two individuals (www.helix.nih.gov/apps/bioinfo/loki.html).html
A linkage analysis was carried out among 424 individuals from 100 sib-pair Danish families.
A linkage analysis revealed significant linkage disequilibrium between the loci LXAGA1 and Myrt3 (P = 0.005).
Second, the EST's are being screened for variation that can be used in a linkage analysis.
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Combining the two datasets in a single linkage analysis produced a highly contiguous map.
We then performed a parametric linkage analysis using a fully penetrant, monogenic autosomal recessive model of inheritance in the family with its 10 informative meioses.
11.034 detected SNPs were included in a parametric linkage analysis which resulted in a significant linkage peak at chromosome six.
One year later, Murabito et al. [ 11] carried out a genomewide linkage analysis of ANM in a populationbased sample.
We conducted a genomewide linkage analysis to identify pelvic organ prolapse (POP) predisposition genes using a resource of high-risk POP pedigrees.
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