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Another adopts the variance of several adjacent A-line phase differences [ 11, 12].
This is quite different from the inter-A-line phase changes within a fast beam scanning frame, which usually is gradual.
PRCD OCT uses the adjacent A-line phase difference to extract the average Doppler frequency: where f ¯ is Doppler frequency, and are the phases for the signal at the depth z of the (j + 1 th and jth A-line, and T is the time interval between adjacent A-lines.
A distributed transmission line phase shifter based on two series connected parallel-plate ferroelectric thin film varactors, which are integrated into single crystal (1 0 0) LAOlO3 (LAO) wafer, is presented.
In a recent first line phase II study in metastatic GIST the drug showed remarkable activity with a disease control rate of 97 % and an estimated PFS of 41.3 months [ 18].
For each cell, the relationship between frequency and BP is fitted to a line in phase space, which yields a phase intercept called the CP and a slope called the characteristic delay (CD): BP (f ) ≈ CP + CD.
This was the reason for the choice of such a schedule for the front line phase 3 study.
Based on these results in first line treatment of GIST and based on promising activity in imatinib-resistant GIST patients in the phase I study [ 19], it was decided to start two randomised studies in metastatic GIST a first line phase III study (NCT00812240) comparing masitinib to imatinib and a second line phase II study (NCT01506336) comparing mastinib to sunitinib.
A first-line phase III trial of exemestane versus tamoxifen in postmenopausal patients with hormone receptor-positive or -unknown advanced breast cancer is ongoing.
In a first-line phase 2 study of 25 mg weekly temsirolimus in 41 advanced STS patients, median time to progression was only 2 months, with 6-month PFS rate of 13% seen (Okuno et al, 2011).
Results from a second-line phase II study randomly assigning patients with hormone-positive MBC to tamoxifen versus tamoxifen plus an mTOR inhibitor (everolimus) showed a significant improvement in the CBR, median TTP, and OS as of a September 2011 update at the European Multi-disciplinary Cancer Congress [ 27, 28].
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