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There's been a recent emphasis on those who play the game's most important position, quarterback, but the N.F.L. will likely define a limited "target area" of the body for legal tackling of all players.
Because of the number of permutations involved, the published studies of long oligonucleotide probes use a very limited number of sequences, consider only greater than three mismatches, or use a limited target concentration range [18], [28].
The so-called RTX 'hemolysins' were initially found to exhibit a limited target cell and species specificity, while the activity of leukotoxins was considered to be species and cell-type specific (Welch, 1991; Coote, 1992;).
Based on experimental evidence exclusively obtained with pharmacologic inhibitors (which often exhibit a limited target specificity and thereby make interpretation of results difficult), this study also suggests that sAPP α-dependent neuroprotection may require the IGF-1 receptor and the insulin receptor (IR) to mediate its effects.
There is a limited target market, and much competition.
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In contrast, MitoTALENs targeted to the same sequence demonstrated a limited targeting ability for nuclear sequences, with only 3%6%% of the transfected cells shown to be mCherry+/EGFP− (Figs. 3F and S3E).
The evolution of miRNAs that target a large gene family, such as the NBS-LRR gene family, would potentially be exposed to different evolutionary constraints, than miRNAs with a more limited target repertoire.
What are the potential roles for microRNAs in mature erythrocytes, a cell type with limited target mRNA and translation activity?
This method exploits the knowledge from unlabeled target instances to enhance a target HTL task with limited target labels.
Since conventional screening methods suffer from low throughput and limited target metabolites, a universal high-throughput screening platform for selection of improved strains should be developed to facilitate evolution of metabolite high producer.
For example, Liu et al. [11] use the notation of supervised transfer learning to denote a fully-labeled source domain and a limited labeled target, while unsupervised transfer learning denotes a mostly labeled source with no target domain labels.
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CEO of Professional Science Editing for Scientists @ prosciediting.com