In vivo and in vitro studies using an ovine model system were designed to address a premise that oxidative distresses to DNA inflicted upon ovarian surface epithelial cells within a limited diffusion radius of the ovulatory site of follicular rupture, if gone uncorrected by p53-dependent cycle arrest/repair pathways, could yield a progenitor of tumorigenic potential.
On the other hand, a limited diffusion range of the autoinducer would lead to a short-range, local coupling between the cells, which would in turn provide a patterning mechanism driven by the formation of spatial clusters.
The effect of a limited diffusion length is readily visible in Figure 6.
This method creates a foamed matrix which may not be optimum for growing cell colonies larger than a few hundred micrometres due to the limited diffusion of nutrients and oxygen, and the limited removal of waste metabolites.
At high conversions, the limited diffusion of the polymer chains results in a slower polymerization and a dispersity lower than that expected from bulk.
Therefore, there must be a trade-off between the advantages of living in a biofilm (including sharing of common goods, protection against external aggression, limited diffusion of molecules, etc).
Even so, use of oxygen would not directly lead to higher power outputs, since oxygen-use in the cathode usually leads to high cathode over-potentials due to limited diffusion of oxygen into the electrode and thus oxygen-limitation at the electrode surface.
In addition, biodegradation rates are restricted by limited diffusion of oxygen and nutrients to hydrocarbon-degrading aerobes.
A key challenge in tissue engineering is overcoming cell death in the scaffold interior due to the limited diffusion of oxygen and nutrients therein.
This is possibly ascribed to the limited diffusion of large-sized epoxide substrate molecules into the pore canal of DVB-HTA thus exerting size-selective catalysis.
