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In order to identify novel kinase genes related to ADI prostate cancer growth, we screened a library of activated human kinases.
By screening a library of activated human kinases, we have identified TPL2, encoding a serine/threonine kinase, as driving ADI prostate cancer growth.
In this study, by screening a library of activated human kinases, we identified and characterized a kinase gene, TPL2, that appears to drive ADI prostate cancer growth.
By screening a library of activated kinases, we identified 33 kinases whose constitutive expression decreases cell proliferation and induces expression of senescence markers; p16 and SASP components.
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A gene of an enteric virus-binding protein (EVBP), derived from a monomer of a bacterial chaperon protein GroEL, was successfully acquired from a genomic DNA library of activated sludge microorganisms with nested PCR.
We screened a library of peptide toxins for effects on mechanically activated currents in cultured dorsal root ganglion neurons.
We next conducted a pilot chemical screen for compounds capable of activating GC signaling using a library of Food and Drug Administration FDAapprovedvedrugsgs.
Herein, we report a library of peptide peptoid hybrid prodrugs that can be selectively activated by prostate cancer cells.
We have further developed this assay into a high-throughput format and undertaken a screen of a library of small molecules to look for compounds that can inhibit (or activate) rhomboid activity.
Beginning with a library of more than 1 million random promoter clones, we used fluorescence activated cell sorting (FACS) to select cells expressing specific levels of GFP.
Many other applications could be possible as well; the team has made a library of 70,290 guide RNAs the sequences that guide enzymes to the proper place that collectively activate every gene in the human genome.
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