In multi-level models that considered center as a level of analysis, substantial variance was accounted for by centers, pointing to the importance of considering center-level predictors in future research.
In the absence of radiological PD, patients could develop clinical PD, defined as an overall level of substantial worsening such that the overall tumour burden or complaints increased sufficiently to merit discontinuation of therapy [ 9].
This concentration of health and social problems creates a level of demand which places substantial and continuous pressures on healthcare professionals [ 27].
However, the activation, albeit at a lower level, of a substantial fraction of defence-like genes in WT nodules ("exo1" subgroup) raises interesting questions regarding their role during normal nodule development, discussed below in the section on regulator genes.
Our results indicate that CNAs in myeloma impact the gene expression level of a substantial number of genes.
These results suggest that chromosome copy number changes in myeloma could have direct effect on the expression level of a substantial number of genes.
"It has given us one of the most robust balance sheets in the industry with a modest level of debt and substantial liquidity".
Although previously reported in Malaysian Borneo, leptospirosis was not recognized as a cause of a substantial level of illness in Borneo at the time of Eco-Challenge.
However, for the RHI to be useful in a clinical setting for the treatment of OCD, it would require a high level of reproducibility and a substantial effect size.
The I statistic indicates the proportion of variability across studies not explained by chance alone and the I value of 50% or more was considered to be an indicator of substantial level of heterogeneity [ 12, 13].
A substantial level of PARP cleavage, a characteristic of apoptosis, was also apparent only in the cells treated with PHA-665752.
