Together with the differences in 5-year overall survival rates, the data suggested that a higher level of pathway activation was linked to a better outcome and is in agreement with the association of better prognosis with WNT/ β-catenin pathway activation earlier found in medulloblastoma (Ellison et al, 2005; Gajjar et al, 2006).
These analyses did not demonstrate an association between level of pathway implementation and patient outcomes with exception of pneumonia (p-value for trend 0.006).
We assumed a level of flux into the pathway ∼2/3 rds of the lowest Vmax value obtained across both time courses.
That is, beyond a threshold of fold change used to signify biological difference, information on the magnitude of expression change is likely to be highly dependent on the exact time of measurement and therefore is not a reliable indicator of relative level of pathway activation.
In bacterial chemotaxis, adaptation to the preset level of pathway activity is achieved through an integral feedback mechanism based on activity-dependent methylation of chemoreceptors.
While we observed some differences among cell lines, the baseline level of pathway flux was surprisingly similar between the SQLE-sensitive and SQLE-insensitive cell lines (Fig. 4b).
Typically one measures the level of pathway specific outputs.
Despite the central role played by DPSL, cells maintained a lower level of protection after disruption of the dpsl gene, indicating a level of redundancy in the oxidative stress pathways of S. solfataricus.
The proportions of the pathway with p-values ≤ 0.01 are listed in Table 2. Clearly, the significance of the pathway is lost when centrality is used as a weighting factor, and levels of pathway significance depend on network structure and type of centrality measure.
A substantial amount of information is available about glutamate-dependent pathways and signalling events in a non-renal, specifically neurological context, and it was surprising to encounter a considerable level of glutamatergic pathway elements associated with renal dysfunction.
Drosophila and human SUMO family proteins are at least partially interchangeable, demonstrating a high level of SUMO pathway conservation between evolutionarily distant organisms [16].
