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In the second conserved domain, the fungal proteins show a level of conservation comparable to Magnoliophyta and higher than Eumetazoa.
Against the Arabidopsis database only 927 Tortula clusters generated HSP Bit scores but 612 had a level of conservation sufficient to be considered reliable matches to Arabidopsis genes.
Recent work has also highlighted that many of the TE families in D. melanogaster possess a level of conservation in the sequences of their target sites (Nefedova et al. 2011; Linheiro and Bergman 2012).
When the Tortula clusters were used as queries against the Physcomitrella database, 5,554 generated HSP Bit scores however only 282 exhibited a level of conservation of sequence that passed the criteria established for annotation of our Tortula clusters (HSP Bits score above 70 and or E values of 10-7 or less, see above).
There were 12 A. candida predicted genes that bore similarity to other oomycetes and the fact that there is a level of conservation amongst the oomycetes would suggest there may be a shared evolutionary lineage to some of these genes amongst oomycetes (Additional file 1: Additional Figure S10).
Gene conversion and unequal crossing-over events are the mechanisms proposed to explain such a level of conservation after tens of millions of years, but more in-depth genomic and cytological work would help to determine the type and frequency of these events.
Similar(54)
The LS classification is based on a level of protein conservation with respect to phylogenetic profiles.
Despite their repetitive sequence, coiled-coils show a level of sequence conservation similar to that of globular domains.
This suggests that the signals patterning during early embryonic development have an ancient origin and exhibit a strong level of conservation over evolutionary time.
An alignment of deduced amino acid sequences of ENC genes revealed a high level of conservation of some key residues (fig. 1 A).
Cancer-associated nsSNPs appeared to fall into positions with a higher level of conservation than common nsSNPs, yet could be as conserved as disease-causing nsSNPs (Figure 3A).
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