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The study of these markers using rapid tests in a less selected cohort would be important in this setting.
Furthermore, since our study population is restricted to patients with diabetes being treated at tertiary care facilities, future studies in a less selected population may have greater generalisability.
This study provides valuable new information about the performance of these markers in a developing world setting, and suggests that the study needs to be repeated in a less selected cohort.
Before we can recommend PCT for more widespread use, we recommend that the study is repeated in a less selected cohort of all children presenting with signs suggestive of bacterial infection, and that a randomised controlled trial (RCT) of PCT be conducted to assess the potential for PCT-guided management to reduce mortality.
Nonagenarians are old enough to reflect exceptional longevity, but at the same time represent a less selected group than centenarians.
One may expect effect estimates in a less selected, less healthy population to be larger than those reported.
Similar(45)
For this reason, the preventive tests and services we studied would seem to be even more appropriate than for a less select population where offsetting mortality risk may attenuate the benefit of screening tests.
Background: The impact and prognostic value of the redefinition of myocardial infarction (MI) with more sensitive markers have not been evaluated prospectively in a large, less selected population with acute coronary syndrome (ACS).
Widowhood is a common event at older but not younger ages, particularly for women, this means that people widowed at older ages are a much less selected group than those widowed earlier in life.
This is often forgot, when the results from these strictly selected patient populations are extrapolated into "evidence based" treatment recommendations directed towards a much larger and less selected patient population.
Due to the observational nature of this study, we expected the patient population to be less selected, including a significant proportion of patients with poor PS, as well as elderly patients.
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