The phrase "a leading subset of" is correct and usable in written English.
It can be used when referring to a prominent or influential group within a larger category or set.
Example: "The research focused on a leading subset of companies that are pioneering sustainable practices in their industries."
Alternatives: "a prominent group of" or "a key segment of".
However, down-regulated bronchial genes are enriched among genes most down-regulated in response to smoking in the nasal epithelium (p < 0.001), yielding a leading edge subset of 50 genes.
Finally, we obtained the size of the leading edge subset of each of those 50 gene sets.
The leading edge subset of genes can be defined as the core accounting for the enrichment signal of the significant chromosomal gene set.
The vector ϕ t has length equal to the number of gene sets and models the binary activation status of each gene set; the vector ψ t has length equal to the total number of genes in the dataset and models the leading edge subset of each gene set.
More specifically, the leading edge subset of genes, whose expression levels drive the signal of Wnt upregulation in spt, contains Wnt ligands and Frizzled receptors implicated in both signaling pathways (e.g. canonical wnt8 and fzd10, non-canonical wnt11 and fzd7).
To control for sequence length, we selected again sequences over 1000-bp leadingeading to a subset of 170 genes.
A high proportion of genes significant in WT/APPα/α was also significant in WT/APP-/ leading to a subset of 169 co-regulated genes.
These 350 targets were cross-referenced to the microarray data set, leading to a subset of 52 genes that were differentially regulated in CRC (Supplementary Table 3).
For this reason, we excluded the problematic tissues, leading to a subset of 26 non-gender-specific tissues and 5 gender-specific tissues.
For PLINK, which does not include LD, we did SNP pruning (pairwise r<0.2 in sliding windows of size 50 shifting every 5 SNPs) leading to a subset of 65 959 SNPs.
