Exact(11)
Most of the MGE cells exhibited typical polar morphology, with either unbranched/non-bifurcated (type 1; Fig. 6 A) or branched/bifurcated (type 2; Fig. 6 A) leading process.
Urbanisation is a leading process on the Globe causing a massive loss of natural habitats.
One was initiated by a leading process extending radially while the second was caused by a newly developed radial process from the cell soma.
It was suggested that in the VZ, these neurons extend a leading process to contact the ventricular surface, retract the process, and migrate back towards the CP [11], [12], [20].
Indeed, PCN neurons, dorsally located in the rhombic lips, migrate ventrally through a tangential neurophilic migration [10], emitting first a leading process, the future axon, and then translocating their cell bodies in the leading process [11].
Neurons migrate in a stereotypical saltatory, two-stroke cycle: first, a leading process extends and explores, then the cell soma follows in a distinct translocation event [4], [5], [6].
Similar(49)
For example, Lis1 is necessary to stabilize polymerized microtubules in new branches [ 71] and in Lis1 knock-out mice, tangentially migrating cells exhibit a longer leading process and a reduced number of branches [ 123].
While migrating, immature interneurons maintain a simplified morphology with a single leading process as they migrate in chains (Lois et al., 1996).
When a neuron receives a guidance cue to migrate in a particular direction, the cell polarizes and forms a single leading process, which explores the substrate.
Like in dissociated hNPC cultures, neurons were highly motile with a single leading process guiding their migration path.
Further, most Gsk3 null neurons in the cortical plate elaborated a long leading process directed toward the pial surface (yellow arrowheads).
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