One of the aspects that will make a probe in preclinical development to be considered as a lead compound, with potential for translation into the clinic, is its capacity to accumulate specifically in the tumor, enabling the acquisition of images with good contrast.
Polling last week found Democratic Rep. Kyrsten Sinema with a lead over any potential Republican challenger for Flake's Senate seat.
Encouraged by the afore-mentioned findings and in a continuation of an ongoing program aimed at finding new structural leads with potential potent antibacterial and antifungal agents [28, 29], this study describes the synthesis of a new class of 2-amino-5-arylazo-6-aryl substituted nicotinic acid, pyridazinone, and pyrido[2,3-d]pyrimidine derivatives.
In the search of new leads with potential antimicrobial activity, a new series of 14 4-substituted [N′- benzofuroxan-5-yl)methyleN′- benzofuroxan-5-ylifuroxazide derivatives, were syN′- benzofuroxan-5-ylagaiN′- benzofuroxan-5-ylidrug-resistant Staphylococcus aureus strains.
Collectively, our study indicates that (R -PA-824 R -PA-824s a stR -PA-824 compound with potential forepresentsent astrongch-needed oraleadeatment for VL.
In conclusion, by screening a library of compounds produced for anti-cancer studies, we have identified leads with potential for treating African trypanosomiasis.
To examine new drug leads with potential antibacterial activities, 14 p-substituted benzoic acid [ 5-nitro-thiophen-2-yl -methylene]-hydrazides were designed, synthesized, and tested against standard and multidrug-resistant S. aureus strains by serial dilution tests.
The discovery of innovative leads with potential interaction to specific targets is of central importance to the early-stage drug discovery.
In conclusion, PMH is a novel antimetastatic lead class with potential to control metastatic prostate cancer.
A medicinal chemistry effort centered on the identification of a lead series with the potential of delivering such compounds is described in this Letter.
The club appointed Trevor Birch to lead talks with potential investors interested in a takeover this week, with chairman Phil Gartside seriously ill.
