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However, among the five such patients who developed a later recurrence, four showed elevated levels of serum CYFRA 21-1.
This characteristic makes them a possible source of later recurrence of the disease or therapy-driven selection of resistant clones [ 9].
A notable inference from this particular article notes the lack of correlation between the amount of tissue destroyed at the initial tumor site and the later recurrence of a tumor at that same site [ 8].
The relatively long duration between the primary and recurrent disease may favor the later recurrence of ER-positive HER2-negative breast cancer, reflected in the relatively large proportion of high ER-positive and low HER2-positive cancers.
xTherefore, Cx43+ expression is an important predictor of later recurrence and a better prognosis in patients with a low AFP level who undergo radical hepatectomy.
We found that in patients with a low AFP level, Cx43+ tumor tissues were an independent predictor of later recurrence and a better prognosis.
Despite a controversial marker to predict tumor prognosis, the relatively high level of Ki67 did indicate later recurrence in our case [ 18].
Furthermore, we found that early onset of hypocalcaemia and hypoparathyroidism had a high risk of later recurrence.
Neonatal hypocalcemia is not associated with the later development of permanent hypopara-thyroidism. 38 However, the early onset of hypoparathyroidism is associated with a high risk of later recurrence.
Cx43 expression is an independent predictor of later recurrence and longer overall survival and is inversely correlated with expression of CD105 and VEGF (P = 0.018 and 0.023, respectively), histological differentiation (P = 0.002), vessel tumor embolism (P = 0.029), and focal number (P = 0.017).
Cx43 is an independent predictor of later recurrence and longer OS after HCC radical hepatectomy.
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