Nevertheless, cartilage destruction was not observed in MMP-3 mice even 2 weeks after arthritis induction, suggesting that MMP-3 may play a key role in later progression of cartilage erosion in the antigen-induced arthritis model.
Thus, probands with later progression had an initial negative symptom score of 15.0 compared with those who remained stable (12.34; F = 5.690; p = 0.02).
Positive symptom scores at study entry related with later progression: those probands who would progress during the study period had an initial score of 13.53 compared with 10.64 for those probands who remained stable (F = 9.030; p = 0.004).
Characteristic features on presentation may predict later progression and outcome; identify a distinct high-risk cPACNS cohort; and guide the selection of patients for immunosuppressive therapy.
However, while animal models provide evidence for a plausible biological link between nicotine exposure in utero and later progression to smoking, the extent to which this evidence is generalizable to human behaviour and biology is unclear.
Recurrent lesions (n = 26, stage T1: n = 15), representing underlying field disease, even had a slight tendency towards more stable tumors among those with later progression (p = 0.08 and p = 0.52; corrected for T-stage).
b Four days later, progression of dark hypopyon (blue arrowhead) and development of a brown papillary membrane (arrow).
Analysis of patient's subsequent clinical course revealed later progression to DN in some of the false positive classified DN control patients.
Despite later progression into invasive bladder cancer, no subsequent registration in the DCR will be performed.
Seven low-risk cases with later progression were included and marked with asterisk*.
