Sentence examples for a late replication from inspiring English sources

Recruitment of a HAT to a late replication origin advances its association with Cdc45 and its time of firing in yeast [4].

Importantly, we showed above that NUMT14 acts as a late replication origin in its chromosomal location, and the structure of the DNA fragment analysed herein shows that the bubble arc is centred on the NUMT and not on the neighbour ARS (see Figure S7).

This model, in turn, provides an explanation for the observation that early-replicating regions have a low mutation rate and late replication regions have a high mutation rate: Damaged bases in late-replicating regions are more likely to be subjected to mutagenic translesion synthesis than similar lesions in early-replicating regions.

In order to detect a possible bias toward early or late replication of a chromosome arm, similar to what has been described for L. kluyveri [ 15], T50 were plotted for each chromosome arm separately.

It has recently been demonstrated in the Encode project that the H3K27me3 mark shows a positive correlation with late replication of large DNA segments [53].

In Saccharomyces cerevisiae the deletion of one of the S-phase cyclins, Clb5, causes a strong delay of late replication origins [16].

Cytological observations also revealed a remarkable consistency of late replication patterns in different types of cells such as salivary gland or nurse cells in ovaries in Drosophila and Anopheles [ 48, 49].

Although the exact relationship between chromatin structure and replication timing is not fully understood, early replication is a characteristic of 'accessible' and highly acetylated chromatin while late replication is a feature of heterochromatic domains and some repressed genes [ 28].

By overlaying CpG and expression data onto the trained replication-timing map, we also show that supraHex is able to intuitively capture an inherent relationship between late replication, low CpG density promoters and low expression levels.

Above we demonstrated that Mi{ET1} inserts are strongly biased to testis-specific genes, and potentially high frequency of Mi{ET1} insertions into LR loci could be associated with late replication of a significant proportion of testis-specific genes.

However, we point out that most H3K9me3 sites are normally in late replicating domains and therefore the reduction must basically "mainly" affect late replication domains.