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The distribution of SPMs allowed phylogenetic reconstruction of this tumor's evolutionary pathway and showed that the metastatic samples arose as a late event.
Specifically, Nox1 expression was increased early and decreased with lesion progression, while induction of Nox4 was a late event.
Complete restriction to a B lineage fate appears to be a late event.
Thus, our data supports potassium efflux as a late event in pyroptosis.
This indicates that apoptosis is a late event in Bmi1−/−BXB11 adenomas.
Therefore, damage is a late event [ 16].
Neuronal loss finally appears a late event.
p53 mutation is a late event in PCa progression.
It may be a late event in cervical carcinogenesis.
In other cancers, ascites is a late event when the goal of treatment is palliation [ 67].
Their methylation appears to be a late event in tumour evolution/metastasis.
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