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After a mechanical microlesion of the brain, the elevation of extracellular ATP went along with a lasting elevation of glutamate [11].
Our experiments with short-term INSULIN2 treatment in Ins1−/−: Ins2+/− mice also pointed to possible long-term effects on weight gain, although the limited period of insulin treatment could have led to impaired insulin sensitivity and a lasting elevation of insulin secretion, as previously seen [ 36].
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This pathway links the Notch receptor to phosphorylation of STAT3 on the serine residue and a subsequent rapid increase in the transcription factor Hes3 that causes a long lasting elevation of sonic hedgehog (Shh).
One of the effects is a long lasting elevation of the pain threshold (PT) [ 9, 14- 16].
K2P5.1 is important for T cell functions such as proliferation or cytokine production [ 7] as it is hypothesized that the counterbalancing efflux of potassium channels is mandatory for a longer lasting elevation of the intracellular Ca2+ levels during T cell stimulation [ 7].
Rats, like humans, show heterogeneity in post-trauma anxiety responses and have been previously classified as those with a PTSD-like phenotype based on their lasting elevation of post-trauma acoustic startle responses (ASR) and anxiety-like behavior in the elevated plus maze (EPM).
The long lasting elevation of [Ca2+]i seen after the initial [Ca2+]i peak probably results from a receptor- or second messenger-operated Ca2+ current activated by bradykinin, rather than via a capacitative pathway [ 26].
The lasting elevation of auxin concentrations up to the transition into the ripening phase poses the question whether the Ethrel-induced ripening delay might be the result of higher than normal auxin concentrations in pre-veraison berries.
This effect of PSN632408 on glucose tolerance was associated with a significantly greater plasma insulin response to oral glucose, indicated by a longer-lasting elevation of serum insulin concentrations after glucose ingestion and a significant increase in the area under the resultant curve.
Here we report that individual predispositions to a PTSD-like phenotype, consisting of impaired rate and magnitude of extinction of an emotionally traumatic event coupled with long-lasting elevation of acoustic startle responses, can be revealed following exposure to a mild stressor, but before experiencing emotional trauma.
These results suggest that that the long-lasting elevation of DA and its metabolites in the NAc is attributable mainly to drug-associated context, rather than the residual effect of morphine.
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